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Addiction is a complex and multifaceted disorder that significantly impacts individuals, families, and societies worldwide. Traditionally, addiction was viewed through a behavioral lens, but recent advancements in genetics and neuroscience have provided new insights into its underlying biological mechanisms. This research article explores the role of genetics and neuroscience in addiction therapy, emphasizing the contributions these fields have made to understand the neurobiological pathways of addiction, as well as their implications for the development of more effective therapeutic interventions. By integrating genetic and neuroscientific perspectives, addiction therapy can be personalized, improving outcomes and reducing the likelihood of relapse