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Persistent pelvic discomfort is a complex condition that affects a significant portion of the population, particularly women. The multifactorial nature of this discomfort often leads to a challenging treatment landscape. Cognitive Behavioral Therapy (CBT) has emerged as a viable non-pharmacological intervention for managing persistent pelvic discomfort, addressing both physical and psychological aspects of the condition. This article explores the efficacy of CBT in treating persistent pelvic discomfort, discusses the mechanisms underlying its effectiveness, and reviews clinical evidence supporting its use.